Immunohistochemistry of soft tissues surrounding late failures of Brånemark implants
Identifieur interne : 009E24 ( Main/Exploration ); précédent : 009E23; suivant : 009E25Immunohistochemistry of soft tissues surrounding late failures of Brånemark implants
Auteurs : Marco Esposito ; Peter Thomsen ; Johan Mölne ; Christiana Gretzer ; Lars E. Ericson ; Ulf Lekholm [Suède]Source :
- Clinical Oral Implants Research [ 0905-7161 ] ; 1997-10.
Abstract
The objective of the present investigation was to characterize the cellular composition of the soft tissues surrounding consecutively retrieved late failures of Brånemark implants. Criteria for implant failure were signs of loss of osseointegration (radiographic peri‐fixtural radiolucency and mobility). The clinical history of the implants did not include adverse symptoms. At the time of retrieval, percussion‐induced pain was experienced at 4/S implants, but no macroscopical signs of inflammation or infection was observed. Immunohistochemistry was applied on 6 marginal peri‐implant specimens and on specimens of deeper tissues associated with the previously load‐bearing implant surface from 8 failed implants, whereas 6 clinically healthy mucosal specimens and 4 hyperplastic biopsies from stable implants served as controls. The immunohistochemical evaluation showed that the soft tissues surrounding failed implants contained a large number of macrophages (CD68), HLA‐DR positive cells, lymphocytes and plasma cells preferentially accumulated towards the removed implant surface. PMNs were a rare finding. Downgrowth of epithelium, in some cases encapsulating the whole fixture, was observed in sections where an intact implant/soft tissue interface was preserved. Healthy control mucosal specimens always contained labelled cells, albeit in a low amount, whereas hyperplastic control samples displayed an intense inflammatory and immunological response with numerous positive cells and PMNs scattered throughout the biopsy. In conclusion, failed implants were characterized by a chronic inflammatory response of the surrounding tissues with macrophages as the predominant labelled cell type, while hyperplastic tissues around stable implants were distinguished by an acute inflammatory process. These findings suggest that an on‐going infection is unlikely to be the etiological factor for the late failures of dental implants examined in this study.
Url:
DOI: 10.1034/j.1600-0501.1997.080502.x
Affiliations:
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Ericson</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Lekholm, Ulf" sort="Lekholm, Ulf" uniqKey="Lekholm U" first="Ulf" last="Lekholm">Ulf Lekholm</name><affiliation wicri:level="4"><country xml:lang="fr">Suède</country><wicri:regionArea>The Brånemark Clinic, Faculty of Odontology, Göteborg University</wicri:regionArea><placeName><settlement type="city">Göteborg</settlement><region nuts="1">Götaland</region><region nuts="1">Suède occidentale</region></placeName><orgName type="university">Université de Göteborg</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Oral Implants Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="ISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><imprint><biblScope unit="vol">8</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="352">352</biblScope><biblScope unit="page" to="366">366</biblScope><publisher>Munksgaard International Publishers</publisher><pubPlace>Copenhagen</pubPlace><date type="published" when="1997-10">1997-10</date></imprint><idno type="ISSN">0905-7161</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0905-7161</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of the present investigation was to characterize the cellular composition of the soft tissues surrounding consecutively retrieved late failures of Brånemark implants. Criteria for implant failure were signs of loss of osseointegration (radiographic peri‐fixtural radiolucency and mobility). The clinical history of the implants did not include adverse symptoms. At the time of retrieval, percussion‐induced pain was experienced at 4/S implants, but no macroscopical signs of inflammation or infection was observed. Immunohistochemistry was applied on 6 marginal peri‐implant specimens and on specimens of deeper tissues associated with the previously load‐bearing implant surface from 8 failed implants, whereas 6 clinically healthy mucosal specimens and 4 hyperplastic biopsies from stable implants served as controls. The immunohistochemical evaluation showed that the soft tissues surrounding failed implants contained a large number of macrophages (CD68), HLA‐DR positive cells, lymphocytes and plasma cells preferentially accumulated towards the removed implant surface. PMNs were a rare finding. Downgrowth of epithelium, in some cases encapsulating the whole fixture, was observed in sections where an intact implant/soft tissue interface was preserved. Healthy control mucosal specimens always contained labelled cells, albeit in a low amount, whereas hyperplastic control samples displayed an intense inflammatory and immunological response with numerous positive cells and PMNs scattered throughout the biopsy. In conclusion, failed implants were characterized by a chronic inflammatory response of the surrounding tissues with macrophages as the predominant labelled cell type, while hyperplastic tissues around stable implants were distinguished by an acute inflammatory process. These findings suggest that an on‐going infection is unlikely to be the etiological factor for the late failures of dental implants examined in this study.</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>Götaland</li><li>Suède occidentale</li></region><settlement><li>Göteborg</li></settlement><orgName><li>Université de Göteborg</li></orgName></list><tree><noCountry><name sortKey="Ericson, Lars E" sort="Ericson, Lars E" uniqKey="Ericson L" first="Lars E." last="Ericson">Lars E. Ericson</name><name sortKey="Esposito, Marco" sort="Esposito, Marco" uniqKey="Esposito M" first="Marco" last="Esposito">Marco Esposito</name><name sortKey="Gretzer, Christiana" sort="Gretzer, Christiana" uniqKey="Gretzer C" first="Christiana" last="Gretzer">Christiana Gretzer</name><name sortKey="Molne, Johan" sort="Molne, Johan" uniqKey="Molne J" first="Johan" last="Mölne">Johan Mölne</name><name sortKey="Thomsen, Peter" sort="Thomsen, Peter" uniqKey="Thomsen P" first="Peter" last="Thomsen">Peter Thomsen</name></noCountry><country name="Suède"><region name="Götaland"><name sortKey="Lekholm, Ulf" sort="Lekholm, Ulf" uniqKey="Lekholm U" first="Ulf" last="Lekholm">Ulf Lekholm</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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